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. 2022 Jan 11;13:236. doi: 10.1038/s41467-021-27845-w

Fig. 3. Efficiency of Ag-RDT screening: infection detection versus infection prevention.

Fig. 3

Efficiency of Ag-RDT screening in the context of a highly effective surveillance strategy (intervention #23, routine RT-PCR testing + 2-round Ag-RDT screening on days 1 and 5), comparing (a) apparent screening efficiency with (b) marginal real screening efficiency. Marginal real screening efficiency describes efficiency of Ag-RDT screening for prevention of remaining nosocomial SARS-CoV-2 infections not already averted by routine RT-PCR testing. Screening interventions targeted either all members of staff (blue), all patients (red), or all individuals in the LTCF (orange). Baseline assumptions underlying simulations include: “low” community SARS-CoV-2 incidence and time-varying Ag-RDT sensitivity relative to RT-PCR (Ag-RDT A). Bar heights and error bars correspond to means and 95% confidence intervals estimated by bootstrap resampling (n = 10,000). RT-PCR = reverse transcriptase polymerase chain reaction; Ag-RDT = antigen rapid diagnostic testing; LTCF = long-term care facility.