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. 2021 Nov 20;3(1):sgab052. doi: 10.1093/schizbullopen/sgab052

Fig. 4.

Fig. 4.

NVHL rats exhibit baseline deficits in phase coupling between HIP theta and Cg, PrLC, or NAc gamma, and cannabis vapor exposure selectively alters this delay. A–C) NVHL rats (N = 5 rats, 10 recordings per region) exhibited a 20 ms delay in coupling of HIP theta to high-gamma in the Cg, PrLC, and NAc; both vapor exposures reversed this delay in the B) PrLC and C) NAc, but not in the A) Cg; For all rats, the THC-only vapor exposure also enhanced the HIP theta–gamma coupling strength in all regions, an effect that was also observed to a lesser extent after Balanced THC:CBD vapor exposure; NVHL rats exhibited baseline theta–gamma coupling strength similar to sham rats (N = 5 rats, 10 recordings per region), for all pairwise comparisons. *P < .05; **P < .01 compared to sham control baseline. θ = theta frequency band; γ = gamma frequency band.