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. 2022 Jan 11;13:245. doi: 10.1038/s41467-021-27921-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a MAPK4 mRNA expression across 817 BCa from The Cancer Genome Atlas (TCGA). Boxplot represents 5% (lower whisker), 25% (lower box), 50% (median), 75% (upper box), and 95% (upper whisker). P value by two-sided t test on log2-transformed expression values. n represents independent patients. b, c MAPK4 mRNA expression across 92 BCa PDX models, including 69 TNBC PDX models. MAPK4 is markedly expressed (at around the 50th percentile of all genes expressed) in these PDX tumors (b). IHC was used for evaluating ER, PR, HER2 expression status within these tumors.