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. 2022 Jan 11;13:245. doi: 10.1038/s41467-021-27921-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Proliferation assays on the engineered a HCC1395, b HCC1806, and c SUM159 cells with 0.5 µg/ml Dox-induced expression of MAPK4 (iMAPK4) or control (iCtrl). The cells were also treated with 1 µM of the AKT inhibitors MK2206 (left) or GSK2141795 (right) or control. Data are mean ± SD. d Representative images and quantification of soft-agar assays on Dox-induced SUM159-iMAPK4 cells treated with AKT inhibitors MK2206, GSK2141795, GDC-0068, and DMSO control. Also shown are the control-treated SUM159-iMAPK4 cells without Dox induction. Bar: 500 μm. Data are mean ± SEM. P value by unpaired two-tailed Student’s t test. Data are representative of at least 3 independent experiments. Source data are provided as a Source data file.