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. 2022 Jan 11;13:243. doi: 10.1038/s41467-021-27335-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–d In vivo characterisation of miR-196 and Gdf11 individual and compound mouse mutant skeletal phenotypes. a Representative E18.5 skeletal preparations across genotypes in dorsal view focusing on the presacral vertebral column. C = cervical; T = thoracic; L = lumbar. b, c Quantification of presacral vertebral number b, and total vertebral number c, across genotypes. Raw data is presented in the upper plot (vertical error bar = mean and standard deviation). Mean differences relative to shared reference genotype (here WT) are presented in the lower plot as bootstrap sampling distributions. Each mean difference is depicted as a dot and 95% confidence interval is indicated by the ends of the vertical error bar. n refers to the number of individual animals used for this analysis. d Schematic summary of vertebral alterations observed across the Gdf11;TKO allelic deletion series, relative to WT. Numbers represent the unpaired mean difference for a given genotype, rounded to the next whole number. Diff = difference, S-Ca = sacral-caudal vertebrae, question marks indicate dysmorphic and non-quantifiable elements. b, c Source data are provided as a Source data file.