Table 1.
DeepNull improves association results relative to the Baseline model on ten phenotypes from the UK Biobank.
| Pheno | n | #Hits | %Improve | #Loci | %Improve | ||
|---|---|---|---|---|---|---|---|
| Baseline | DeepNull | Baseline | DeepNull | ||||
| ALP | 416,232 | 1697 | 1759 | 3.65% | 336 | 350 | 4.17% |
| ALT | 416,057 | 371 | 379 | 2.16% | 173 | 174 | 0.58% |
| AST | 414,743 | 337 | 351 | 4.15% | 137 | 145 | 5.84% |
| ApoB | 414,639 | 1172 | 1219 | 4.01% | 200 | 217 | 8.50% |
| Calcium | 381,934 | 726 | 739 | 1.79% | 272 | 281 | 3.31% |
| GRP | 65,896 | 28 | 38 | 35.71% | 26 | 38 | 46.15% |
| LDL | 415,892 | 950 | 993 | 4.53% | 193 | 202 | 4.66% |
| Phosphate | 381,362 | 658 | 664 | 0.91% | 224 | 229 | 2.23% |
| SHBG | 378,459 | 1084 | 1120 | 3.32% | 319 | 323 | 1.25% |
| TG | 416,295 | 1221 | 1254 | 2.70% | 261 | 266 | 1.92% |
| Avg. | 370,151 | 824.4 | 851.6 | 6.29% | 214.1 | 222.5 | 7.86% |
n is the sample size, hits refers to the number of independent genome-wide significant associations detected, and loci is the number of independent regions after merging hits within 250 kb. Bold values in the table indicate the best results.
Phenotypic abbreviations: ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, ApoB Apolipoprotein B, GRP glaucoma referral probability, LDL low-density lipoprotein, SHBG sex hormone-binding globulin, TG triglycerides.