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Lysosomal sorting and degradation of palmitoylated IFNGR1. AP3D1 recognizes the palmitoylation signal and then binds and sorts palmitoylated IFNGR1 to lysosomes for degradation. Optineurin competes with AP3D1 for IFNGR1 binding and prevents IFNGR1 lysosomal sorting and degradation. The loss of optineurin impairs the integrity of the IFNγ signaling pathway in colorectal cancer. Low (left) and high (right) optineurin expression
