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. 2022 Jan 11;13:208. doi: 10.1038/s41467-021-27889-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Summary of all detected age-associated CNAs for driver (A) losses (indicated by blue covariate bar) and (B) gains (red covariate bar) across three datasets. Dot size shows the magnitude of the association as the difference in proportion and the background shading shows adjusted multivariate p values. Right covariate indicates copy number gain drivers in red and loss drivers in blue. C Age-associated CNAs lead to differential mRNA abundance with respect to the CNA itself (top), age (middle), as well as age-specific effects of the CNA (bottom). D In TCGA sarcoma (n = 255 biologically independent samples), CDKN2A mRNA abundance changes between copy number loss (blue) or no loss (black) and broken down by age for low vs. high age. Tukey boxplots are shown with the box indicating quartiles and the whiskers drawn at the lowest and highest points within 1.5 interquartile range of the lower and upper quartiles, respectively. FDR-adjusted p values from two-sided Wilcoxon rank sum test and Spearman correlations shown. E SUFU loss in glioblastoma (GBM; n = 574 biologically independent samples) interacts with age to further stratify patient prognosis. The adjusted p value for the copy number loss-age interaction term is shown. Source data are provided as a Source Data file.