FIGURE 4.

Overall perception of response to therapy. The overall evaluation of perceived response to therapy was rated on a 7-point scale and compared with baseline. Responses included: 1=significantly improved; 2=moderately improved; 3=mildly improved; 4=no change; 5=mildly worse; 6=moderately worse; 7=significantly worse. Data were classified as missing when a rating was not given/obtained or when patients were switched back to open-label mepolizumab treatment (Part D). ^#p<0.001 for all time points. ^¶A more favourable response to therapy rating indicates a response in the direction of improvement on this rating scale at the given time point. Analysed using a proportional odds model (multinomial (ordered) logistic generalised linear model), with terms for treatment group and adjustment for baseline covariates. For analysis purposes, significantly worse and missing were combined into one category.