Figure 1.

Adjusted predicted LDL cholesterol over time after TDF-to-TAF switch, estimated from a linear regression model with linear splines, all switches (n = 6451).^{a a}Estimated from a linear regression model fit with generalized estimated equations, with linear splines on time (knots at 3, 9, 16 months); reference covariate pattern: male aged 45, on TDF for 24 months and with an LDL value of 98 mg/dL at the last lipid panel before switch, a viral load <50 copies/mL throughout follow-up, and no hormone, statin, nonstatin lipid-lowering agent, pharmaco-enhancer, or PI use at any point during follow-up. Abbreviations: LDL, low-density lipoprotein; PI, protease inhibitor; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.