Table 2.
Results of regression models, hazard ratios and 95% confidence intervals, risk of dementia dependent on the duration of diabetes
| Variable | Hazard Ratio (95% CI) | Hazard Ratio (95% CI) | Hazard Ratio (95% CI) |
|---|---|---|---|
| Model 1 (all) | Model 2 (65–84 years) | Model 3 (85+) | |
| Time since T2D (d) | 0.918*** (0.904–0.932) |
0.924*** (0.909–0.940) |
0.899*** (0.864–0.935) |
| Time since T2D 2 (d2) | 1.002*** | 1.002*** | 1.003*** |
| (1.002–1.003) | (1.001–1.002) | (1.001–1.004) | |
| Model 4 (all) | Model 5 (65–84 years) | Model 6 (85+ years) | |
| Time since T2D (d) | 0.926*** (0.910–0.943) |
0.933*** (0.914–0.952) |
0.908*** (0.870–0.948) |
| Time since T2D 2 (d2) | 1.002*** (1.001–1.003) |
1.002*** (1.001–1.002) |
1.003*** (1.001–1.004) |
| Treatment (tg i ) (ref. no ADM tg 0 ) | |||
| Insulin (tg1) | 3.609** (2.305–5.651) |
3.819*** (2.289–6.372) |
4.347*** (1.634–11.565) |
| Non-insulin ADM (tg2) | 1.168 (0.926–1.471) |
1.164 (0.893–1.519) |
1.119 (0.674–1.858) |
| Mixed ADM (tg3) | 2.186* (1.000–4.775) |
2.030 (0.811–5.077) |
2.937 (0.657–13.122) |
| Treatment (tg i ) × Time since T2D (d) | |||
| Insulin (d, tg1) | 0.862*** (0.794–0.937) |
0.883*** (0.807–0.966) |
0.660*** (0.495–0.879) |
| Non-insulin ADM (d, tg2) | 0.981 (0.945–1.018) |
0.979 (0.940–1.019) |
1.002 (0.901–1.115) |
| Mixed ADM (d, tg3) | 0.966 (0.849–1.100) |
0.981 (0.849–1.134) |
0.883 (0.631–1.237) |
| Treatment (tg i ) × Time since T2D 2 (d2) | |||
| Insulin (d2, tg1) | 1.004*** (1.001–1.006) |
1.003** (1.00–1.006) |
1.014** (1.003–1.024) |
| Non-insulin ADM (d2, tg2) | 1.000 (0.999–1.002) |
1.001 (0.999–1.002) |
0.999 (0.995–1.004) |
| Mixed ADM (d2, tg3) | 0.999 (0.995–1.004) |
0.999 (0.994–1.003) |
1.002 (0.990–1.014) |
95% CI: 95% Confidence interval.
* P value <0.10.
** P value <0.05.
*** P value <0.01.
All models controlled for: age, sex, comorbidity and aDCSI.
Models 1, 2 and 3 explore the total duration effect. Models 4, 5 and 6 explore the duration effect by treatment groups.