FIGURE 2.

Addressed targets by the customized protease inhibitor within the kallikrein‐kinin system (A). Targets were assigned based on known characteristics of inhibitors. The kininases involved in kinin metabolism are shown with their catalytic type and cleavage site in (B). BK, bradykinin; FA, formic acid; FXIIa, activated factor XII; HDMB, hexadimethrine bromide; HK, high‐molecular‐weight kininogen; KBK, kallidin; LK, low‐molecular‐weight kininogen; PKa, plasma kallikrein, TK, tissue kallikrein