Figure 4.

Effect of recombinant follicle stimulating hormone (r-FSH) priming followed by r-FSH plus human chorionic gonadotrophin (hCG) treatment on serum anti-Müllerian hormone (AMH), as a Sertoli cell biomarker, and testosterone (T), as a Leydig cell biomarker, in patients with central hypogonadism. Initial r-FSH treatment with 150 IU/day for 30 days increased Sertoli cell AMH secretion. The addition of hCG resulted in an increase of Leydig cell T secretion, which induced Sertoli cell maturation as reflected in the decline in AMH levels. The grey areas represent normal AMH levels for males with prepubertal T levels, corresponding to pubertal Tanner stage 1, on the left and to Tanner 4–5 levels on the right. *p < 0.05; **p < 0.01; ***p < 0.001. Modified with permission from Young et al. ¹³⁰ © 2005 The Endocrine Society.