Figure 5.

Effects of the AAV-PHP.eB-SaCas9-KKH-g2 virus on hair bundle morphology of Myo6^WT/C442Y mice

Scanning electron microscope images of the cochlea sensory epithelium showing the hair bundle morphology for untreated Myo6^WT/WT (left), untreated Myo6^WT/C442Y (middle), and AAV.PHP.eB-SaCas9-KKH-Myo6-g2-treated Myo6^WT/C442Y mice (right) at 10 weeks. Representative bundles (arrows) of OHCs and IHCs were enlarged in the corresponding lower panel. Scale bar in low-magnification figures, 10 μm. Scale bar in high-magnification figures, 4 μm. High, high magnification; Low, low magnification.