Figure 6.

Summary of pathogenic mutations in the TGM1 gene

(A) Summary of the mutation type of TGM1 gene. All the mutations have been reported and recorded in the HGMD point mutations, including deletions, insertions, and indels. (B) The summaries of 12 kinds of point mutations. The g-a and c-t mutation occupy about 51%. The t-c and a-g mutation occupy about 14%. (C) Analysis of repairing effects of mutation sites by ABE/CBE. Potential repairing sgRNAs were analyzed based on mutant sites and PAM sequence. For mutations that could be corrected using ABE or CBE, the precision of correction was analyzed based on whether other bases could be modified. The three bases around the target site were considered.