FIGURE 7.

Mitochondrial fission promotes the growth and metastasis of HCC by reprogramming lipid metabolism. (A) Cell proliferation ability was determined by MTS assay in SNU‐368 cells treated as indicated. (B) Colony formation ability was determined in SNU‐368 cells treated as indicated. (C) Cell migration ability was determined by scratch wound healing assay in SNU‐368 cells treated as indicated. (D) Cell invasion ability was determined by transwell Matrigel invasion assay in SNU‐368 cells treated as indicated. Scale bars, 100 μm. (E) The growth curves of subcutaneous tumor xenografts established from SNU‐368 cells with DNML1 knockdown. (F) Tumor tissues were dissected from mice and their weights were compared. (G) Number of lung metastases in the two groups was compared. Scale bars, 100 μm. *, P < 0.05. Abbreviations: HCC, hepatocellular carcinoma; DRP1, dynamin‐related protein 1; SREBP1, sterol regulatory element‐ binding protein 1; PPARα, perixisome proliferation‐activated receptor α