Figure 4.

KitStop ESOs reduce liver infiltration of neoplastic MCs in a humanized xenograft model of MC neoplasia

(A–D) Examples of liver sections from NSG mice showing neoplastic MC infiltrates with H&E (A) and IHC for human KIT (B) in the vehicle control liver and almost no infiltrates in the KitStop-treated livers (C and D). (E) Histopathological assessment of % of neoplastic infiltration in liver. (F) Histopathological assessment of neoplastic foci size in livers. Graphical representation of data includes boxplots where middle bar represents median and whiskers represent minimum and maximum. All data are derived from five NSG female mice per group. The p value was determined by a Fisher’s least significant difference (LSD) test with ordinary one-way ANOVA or an uncorrected Dunn’s test with a Kruskal-Wallis one-way ANOVA. ∗p ≤ 0.05. Scale bars, 2 mm.