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. 2021 Aug 25;30(1):388–399. doi: 10.1016/j.ymthe.2021.08.025

Figure 2.

Figure 2

Oral transfer of feces and fecal RNA from recovered mice prevents DSS-induced colitis

(A) Schematic design. (B–D) The effects of the transfer of feces from different stages (day 0, day 5, and day 12) of DSS-induced colitis mice on colitis in recipient mice. (B) Body weight change. (C) Disease activity index. (D) Representative colons. (E). Representative colonic morphology. Abbreviations: FMT Day 0, FMT Day 5, and FMT Day 12, mice were transplanted with feces collected from well-recovered mice on days 0, 5, and 12 of the treatment regimen. (F–I) The effects of oral administration of fecal RNA on colitis. (F) Body weight change. (G) Disease activity index. (H) Representative colons. (I) Representative colonic morphology. Abbreviations: FRNAT Day 0, FRNAT Day 5, and FRNAT Day 12, mice were transplanted with RNA extracted from feces collected from well-recovered mice on days 0, 5, and 12 of the treatment regimen. Data were analyzed with one-way ANOVA. Values are mean ± SEM, n = 6. ∗p < 0.05.