Skip to main content
. 2021 Jul 16;30(1):400–414. doi: 10.1016/j.ymthe.2021.07.004

Figure 4.

Figure 4

ADAR2 overexpression attenuates DOX-induced cardiotoxicity

(A) The schedule of virus injection and DOX-induced cardiotoxicity model establishment. (B) Echocardiography of mice treated with AAV9-cTnT-ADAR2 followed by DOX or saline treatment (n = 10:9:10:12, ∗∗p<0.01). (C) TUNEL staining (green) together with α-actinin (red) and DAPI (blue) of mice hearts treated with AAV9-cTnT-ADAR2 or AAV9-cTnT-ctrl followed by DOX or saline treatment (n = 6, ∗∗p < 0.01); scale bar, 20 μm. (D) Western blot of Bax, Bcl2, caspase 3, and cleaved-caspase 3 of mice hearts treated with AAV9-cTnT-ADAR2 followed by DOX or saline treatment (n = 3, ∗p < 0.05, ∗∗p < 0.01).