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. 2022 Jan 10;10(1):e003687. doi: 10.1136/jitc-2021-003687

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Correlations of ICR classes with immunity-related parameters. For each ICR class, they indicated the percentage of samples with lymphocyte infiltrate (A), metagene expression scores of B-cells (B), T-cells (C), Th1 cells (D), CD8 +T cells (E), cytotoxic cells (F), activated dendritic cells (DC) (G), Tγδ cells (H), macrophages (I), activation score of IFNα (J), IFNγ (K), and TNFα (L) pathways, TIS (M) and TLS (N) signatures, antigen processing machinery score (O), and the cytolytic activity score (P). The p values are indicated (Fisher’s exact test or analysis of variance test when appropriate). APMS, Antigen Processing Machinery Score; DC, dendritic cell; IFN, interferon; Th1, T helper 1; TIS, T-cell-inflamed signature; TLS, tertiary lymphoid structure; TNF, tumor necrosis factor.