Table 1.
Characteristics | All patients (n=37) |
Age, years, median (range) | 52 (35–69) |
<65 | 33 (89.2) |
≥65 | 4 (10.8) |
ECOG PS | |
0 | 3 (8.1) |
1 | 33 (89.2) |
Tumor type | |
Ovarian carcinoma | 33 (89.2) |
Fallopian tube carcinoma | 4 (10.8) |
FIGO stage at first diagnosis | |
I | 2 (5.4) |
II | 6 (16.2) |
III | 24 (64.9) |
IV | 5 (13.5) |
Location of metastases | |
Lymph node | 29 (78.4) |
Peritoneum | 21 (56.8) |
Liver | 13 (35.1) |
Spleen | 7 (18.9) |
Abdominal cavity | 6 (16.2) |
Lung | 5 (13.5) |
Number of lines of prior systemic therapy | |
1 | 4 (10.8) |
2 | 11 (29.7) |
3 | 10 (27.0) |
4 | 6 (16.2) |
≥5 | 6 (16.2) |
Platinum resistant status* | |
Primary platinum resistant | 11 (29.7) |
Secondary platinum resistant | 15 (40.5) |
Primary platinum refractory | 11 (29.7) |
Previous bevacizumab use | 6 (18.2) |
Histologic type | |
Serous adenocarcinoma | |
High‐grade | 22 (59.5) |
Low-grade | 1 (2.7) |
Unknown | 5 (13.5) |
Endometrioid carcinoma | 1 (2.7) |
Undifferentiated carcinoma | 1 (2.7) |
Other epithelial ovarian cancer | |
High-grade adenocarcinoma | 5 (13.5) |
Adenocarcinoma (not otherwise specified) | 2 (5.4) |
PD-L1 expression †, n (%) | |
PD-L1 CPS≥1 | 8 (21.6) |
PD-L1 CPS<1 | 11 (29.7) |
Unknown | 18 (48.6) |
Data are n (%) unless otherwise indicated.
*Patients were categorized as primary platinum resistance (disease progression occurring ≥2 months and <6 months after completing first-line platinum therapy), secondary platinum resistance (progression ≥6 months after completing first-line platinum-based chemotherapy but <6 months after completing second-line or later-line platinum-based chemotherapy) and primary platinum refractory (progression <2 months or no response during the first-line platinum-based chemotherapy).
†Mandatory fresh biopsy or archival tissue for PD-L1 expression was not requested at enrollment.
CPS, Combined Positive Score; ECOG, Eastern Cooperative Oncology Group; FIGO, International Federation of Gynecology and Obstetrics; PD-L1, programmed death-ligand 1.