Table 2.

Sixty day case fatalities in each 12 month period (March to February) for conditions with case fatality counts exceeding five each year

Condition	60 day case fatalities	March 2017 to February2018	March 2018 to February 2019	March 2019 to February 2020	March 2020 to February 2021		Model 1*			Model 2*
							Adjusted odds ratio (95% CI)	P value		Adjusted odds ratio (95% CI)	P value
Sepsis	No of deaths/cases	148/11 722	163/12 028	158/11 402	110/7798		1.03 (0.84 to 1.27)	0.77		1.00 (0.81 to 1.24)	0.98
	Rate per 10 000 cases (95% CI)	126 (107 to 148)	136 (116 to 158)	139 (118 to 162)	141 (116 to 170)
Meningitis	No of deaths/cases	29/3976	38/3899	31/3875	21/1964		1.28 (0.79 to 2.05)	0.31		1.07 (0.66 to 1.73)	0.78
	Rate per 10 000 cases (95% CI)	73 (49 to 105)	97 (69 to 134)	80 (54 to 113)	107 (66 to 163)
Bronchiolitis	No of deaths/cases	69/46 614	55/53 703	65/54 648	16/9423		1.35 (0.81 to 2.26)	0.25		1.18 (0.71 to 1.98)	0.52
	Rate per 10 000 cases (95% CI)	15 (12 to 19)	10 (8 to 13)	12 (9 to 15)	17 (10 to 28)
Pneumonia	No of deaths/cases	196/16 257	212/16 261	172/16 692	156/6540		1.71 (1.43 to 2.05)	P<0.001		1.62 (1.35 to 1.94)	P<0.001
	Rate per 10 000 cases (95% CI)	121 (104 to 139)	130 (114 to 149)	103 (88 to 120)	239 (203 to 278)
Viral wheeze	No of deaths/cases	17/74 489	14/81 722	14/76 254	9/34 367		1.47 (0.71 to 3.01)	0.30		1.51 (0.73 to 3.1)	0.26
	Rate per 10 000 cases (95% CI)	2 (1 to 4)	2 (1 to 3)	2 (1 to 3)	3 (1 to 5)
Upper RTI	No of deaths/cases	40/55 369	42/59 138	26/60 208	15/19 677		1.22 (0.71 to 2.09)	0.48		1.19 (0.69 to 2.04)	0.53
	Rate per 10 000 cases (95% CI)	7 (5 to 10)	7 (5 to 10)	4 (3 to 6)	8 (4 to 13)

RTI=respiratory tract infection.

^*Model 1: adjusted for age and sex; model 2: adjusted for age, sex, and comorbidities in table 1. All odds ratios compare 60 day case fatality from March 2020 to February 2021 with reference period from March 2017 to February 2020.