Table 1.
Description of the Characteristics of Studies Included in This Review
| Study | Animals | SCI | No. of Animals | Groups | Outcome | Motor Function Assessment Time |
|---|---|---|---|---|---|---|
| Sun JZ 201965 |
Male SD rats (210–230g) | T8 weight-drop impactor 250g/cm | 10/10/10 | A: Sham + Saline (10mg/kg i.p.) B: SCI + Saline (10mg/kg i.p.) C: SCI + Gs Rg1 (10mg/kg i.p.) for 7 days |
Biochemistry: MDA, SOD, IL-1β, IL-10 | - |
| Liu X 201866 |
Female/male SD rats (220-260g) | T10 weight-drop impactor 10g∗5cm | 10/10/10/10 | A: Sham B: SCI + Saline (10mg/kg i.p.) C: SCI + G-Rb1 (10mg/kg i.p.) D: SCI + G-Rb1 (10mg/kg i.p.) + inhibitor L-name (7 mg/kg i.p.) for 7 days |
Behavioral: BBBs Immunohistochemistry: HE Staining, Immunohistochemical Staining Biochemistry: SOD, MDA, glutathione, catalase, RT-qPCR analysis |
1d, 7d, 14d, 21d, 28d |
| Wang P 201767 |
Male SD rats (200-220g) | T7-T10 aneurysm clip injury 30g∗1 min | 6/6/6/6 | A: Sham + Saline (20mg/kg i.p.) B: SCI + Saline (20mg/kg i.p.) C: Sham + Rb1 (20mg/kg i.p.) D: SCI + Rb1 (20mg/kg i.p.) for 28 days |
Behavioral: BBBs Immunohistochemistry: HE and Nissl Staining, Double Immunofluorescence Staining Biochemistry: Cell Culture and Cell Viability Assessment, Scratch Test, Caspase-3, |
1d, 7d, 14d, 21d, 28d |
| Cong L 201668 |
Female SD rats (250–300g) | T8 weight-drop impactor 10g∗5cm | 18/18/18/18/18/18 | A: Sham B: SCI C: SCI + Gs Rd-L (12.5 mg/kg i.p.) D: SCI + GS Rd-M (25 mg/kg i.p.) E: SCI + GS Rd-H (50 mg/kg i.p.) F: SCI + DEX (1mg/Kg i.p) for 14 days |
Behavioral: BBBs Immunohistochemistry: HE Staining, TNF-a, IL-1b, IL-6 Biochemistry: MDA, GSH, SOD |
1d, 4d, 7d, 10d, 14d |
| Sun JZ 201569 |
Male SD rats (220–240g) | T7-T11 weight-drop impactor 25g/cm | 20/20/20 | A: Sham B: SCI + Saline C: SCI + Gs Rg1 (10 mg/kg i.p.) for 14 days |
Behavioral: BBBs Immunohistochemistry: SOD, MDA |
24h, 48h, 72h, 14d |
| Liu YL 201570 |
Female SD rats (220–260g) | T8-L1 weight-drop impactor 40g/cm | 15/15/15 | A: Sham B: SCI + Gs Rg1 (10mg/kg i.p.) C: SCI for 14 days |
Behavioral: BBBs Immunohistochemistry: HE Staining, Immunofluorescence Staining Biochemistry: SOD, MDA, Caspase-3, Bcl-2 |
1d, 3d, 7d, 14d |
| Li Q 201371 |
Female SD rats (200-250g) | T7-T8 weight-drop impactor 5g∗10cm | 18/18/18/18 | A: SCI + Rb1-L (20 mg/kg i.p.) B: SCI + Rb1-M (40 mg/kg i.p.) C: SCI + Rb1–H (80 mg/kg i.p.) D: SCI + Saline (40mg/kg i.p) for 28 days |
Behavioral: BBBs Biochemistry: SOD, MDA |
1d, 7d, 14d, 28d |
| Song YX 200972 |
Male SD rats (200–250g) | T8-T10 weight-drop impactor 5g∗10cm | 36/36/36 | A: Sham B: SCI C: SCI + Gs (5 mg/kg i.p.) for 14 days |
Behavioral: BBBs, Inclined Plane Test Biochemistry: Bcl-2, BaxPr, Capase-3 |
1d, 3d, 7d, 14d |
| Sakanaka M 200773 |
Male Wistar rats (250-300g) | T12 aneurysm clip injury 20g∗20 min | 8/8/8 | A: SCI + gRb1 (1.2μg/day i.p) B: SCI + gRb1 (6μg/day i.p) C: SCI + Saline (6μg/kg i.p) for 7 days |
Behavioral: Open Field Locomotor Score, BBBs, Brain Temperature, Water Maze Test Immunohistochemistry: TTC Staining Biochemistry: MAP2, VEGF, Bcl-xl |
1d, 2d, 4d, 7d |
| Guo DQ 200474 |
Female/male SD rats (250–320g) | Modified Allen's compression method | 6/18/18/18 | A: Sham B: SCI C: SCI + Gs (2.5mg/kg i.p.) D: SCI + MP (15mg/kg i.p.) for 14 days |
Immunohistochemistry: HE Staining Biochemistry: SOD, MDA, ET, NGF |
- |
SD, Sprague-Dawley; T, thoracic vertebrae; SCI, spinal cord injury; GS Rd, Ginsenoside Rd; i.p., intraperitoneal; BBBs, Basso-Beattie-Bresnahan locomotor rating scale; HE staining, hematoxylin-eosin staining; SOD, Superoxide Dismutase; MDA, malondialdehyde.