Table 2:
Summary of molecular results. AcCC: acinic cell carcinoma, AdCC: adenoid cystic carcinoma, CA-ex-PA: carcinoma ex pleomorphic adenoma, HCCC: hyalinizing clear cell carcinoma, IC: intraductal carcinoma, MEC: mucoepidermoid carcinoma, N/A: not assessed, PA: pleomorphic adenoma, SC: secretory carcinoma, SDC: salivary duct carcinoma.
| Case | Diagnosis | RNA-Seq | 5’ Gene (NCBI Reference) |
3’ Gene (NCBI Reference) |
FISH |
|---|---|---|---|---|---|
| 1 | PA | PRB2-TAF15 * | - | - | TAF15− |
| 2 | PA | Negative | - | - | N/A |
| 3 | PA | NPM1-PRB2 * | 9 of 11 (NM_002520.6) | 3 of 4 (NM_006248.3) | Negative |
| 4 | PA | DSTN-PLAG1 | 1 of 4 (NM_006870.3) | 3 of 5 (NM_002655.2) | PLAG1− |
| 5 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 2 of 5 (NM_002655.2) | N/A |
| 6 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 3 of 5 (NM_002655.2) | N/A |
| 7 | PA | HMGA2-WIF1 | 3 of 5 (NM_003483.4) | 10 of 10 (NM_007191.4) | N/A |
| 8 | PA | HMGA2-WIF1 | 3 of 5 (NM_003483.4) | 10 of 10 (NM_007191.4) | N/A |
| 9 | PA | Negative | - | - | N/A |
| 10 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 3 of 5 (NM_002655.2) | N/A |
| 11 | PA | NTF3-PLAG1 | 1 of 2 (NM_001102654.1) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 12 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 3 of 5 (NM_002655.2) | N/A |
| 13 | PA | LIFR-PLAG1 | 1 of 20 (NM_002310.5) | 3 of 5 (NM_002655.2) | N/A |
| 14 | PA | Negative | - | - | N/A |
| 15 | PA | Negative | - | - | N/A |
| 16 | PA | Negative | - | - | N/A |
| 17 | PA | Negative | - | - | N/A |
| 18 | PA | ACTA2- PLAG1 | 1 of 9 (NM_001613.4) | 3 of 5 (NM_002655.3) | N/A |
| 19 | PA | NCALD- PLAG1 | 1 of 4 (NM_032041.2) | 3 of 5 (NM_002655.2) | N/A |
| 20 | PA | HMGA2-WIF1 | 3 of 5 (NM_003483.4) | 3 of 10 (NM_007191.4) | N/A |
| 21 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 3 of 5 (NM_002655.2) | N/A |
| 22 | PA | CHCHD7-PLAG1 | 3 of 5 (NM_001011667.2) | 3 of 5 (NM_002655.2) | N/A |
| 23 | PA | Negative | - | - | N/A |
| 24 | PA | NCALD-PLAG1 | 1 of 4 (NM_032041.2) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 25 | PA | CTNNB1-PLAG1 | 1 of 15 (NM_001904.3) | 3 of 5 (NM_002655.2) | N/A |
| 26 | PA | FBXO32-PLAG1 | 1 of 9 (NM_058229.3) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 27 | PA | NCALD- PLAG1 | 1 of 4 (NM_032041.2) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 28 | CA-ex-PA | FGFR1-PLAG1 | 2 of 18 (NM_023110.2) | 3 of 5 (NM_002655.2) | N/A |
| 29 | CA-ex-PA | FBXO32-PLAG1 | 1 of 9 (NM_058229.3) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 30 | CA-ex-PA | HMGA2-NFIB | 3 of 5 (NM_003483.4) | 9 of 11 (NM_001190737.1) | N/A |
| 31 | CA-ex-PA | MEG3-PLAG1 | 1 of 7 (NR_002766.2) | 3 of 5 (NM_002655.2) | PLAG1+ |
| 32 | CA-ex-PA | PLAG1-NFIB | 1 of 5 (NM_002655.2) | 3 of 11 (NM_001190737.1) | PLAG1+, NFIB+ |
| 33 | CA-ex-PA | HMGA2-CNOT2 | 2 of 5 (NM_003483.4) | 12 of 16 (NM_001199303.1) | HMGA2 amplification |
| 34 | SDC-ex-PA | Negative | - | - | N/A |
| 35 | AdCC | MYB-NFIB | 13 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 36 | AdCC | MYBL1-NFIB | 14 of 16 (NM_001080416.3) | 9 of 11 (NM_001190737.1) | N/A |
| 37 | AdCC | MYB-NFIB | 15 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 38 | AdCC | MYBL1-NFIB | 8 of 16 (NM_001080416.3) | 11 of 11 (NM_001190737.1) | N/A |
| 39 | AdCC | MYB-NFIB | 15 of 16 (NM_001130173.1) | 10 of 11 (NM_001282787.1) | N/A |
| 40 | AdCC | MYB-NFIB | 15 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 41 | AdCC | MYB-NFIB | 15 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 42 | AdCC | MYB-NFIB | 13 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 43 | AdCC | MYB-NFIB | 8 of 16 (NM_001130173.1) | 10 of 11 (NM_001282787.1) | N/A |
| 44 | AdCC | MYBL1-NFIB | 8 of 16 (NM_001080416.3) | 10 of 11 (NM_001282787.1) | N/A |
| 45 | AdCC | Negative | - | - | N/A |
| 46 | AdCC | MYB-NFIB | 8 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 47 | AdCC | MYB-NFIB | 15 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 48 | AdCC | MYB-NFIB | 8 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 49 | AdCC | MYB-NFIB | 9 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 50 | AdCC | MYBL1-NFIB | 8 of 16 (NM_001080416.3) | 9 of 11 (NM_001190737.1) | N/A |
| 51 | AdCC | NFIB-TBPL1 | 10 of 11 (NM_001190737.1) | 7 of 7 (NM_001253676.1) | NFIB+ |
| 52 | AdCC | MYBL1-NFIB | 12 of 16 (NM_001080416.3) | 2 of 11 (NM_001190737.1) | N/A |
| 53 | AdCC | MYB-NFIB | 13 of 16 (NM_001130173.1) | 11 of 11 (NM_001190737.1) | N/A |
| 54 | AdCC | MYBL1-VCPIP1 | 9 of 16 (NM_001080416.3) | 3 of 3 (NM_025054.4) | MYBL1+ |
| 55 | MEC | Negative | - | - | MAML2+ |
| 56 | MEC | CRTC1-MAML2 | 2 of 14 (NM_015321.2) | 1 of 5 (NM_032427.3) | MAML2+ |
| 57 | MEC | Negative | - | - | MAML2+ |
| 58 | MEC | CRTC3-MAML2 | 2 of 15 (NM_022769.4) | 2 of 5 (NM_032427.3) | MAML2+ |
| 59 | MEC | Negative | - | - | Negative |
| 60 | MEC | CRTC1-MAML2 | 2 of 14 (NM_015321.2) | 1 of 5 (NM_032427.3) | MAML2+ |
| 61 | MEC | CRTC1-MAML2 | 1 of 14 (NM_015321.2) | 2 of 5 (NM_032427.3) | MAML2+ |
| 62 | MEC | Negative | - | - | MAML2+ |
| 63 | MEC | CRTC1-MAML2 | 1 of 14 (NM_015321.2) | 2 of 5 (NM_032427.3) | MAML2+ |
| 64 | MEC | Negative | - | - | Negative |
| 65 | MEC | CRTC3-MAML2 | 2 of 15 (NM_022769.4) | 2 of 5 (NM_032427.3) | MAML2+ |
| 66 | MEC | CRTC1-MAML2 | 1 of 14 (NM_015321.2) | 2 of 5 (NM_032427.3) | MAML2+ |
| 67 | MEC | CRTC1-MAML2 | 1 of 14 (NM_015321.2) | 2 of 5 (NM_032427.3) | MAML2+ |
| 68 | MEC | CRTC3-MAML2 | 2 of 15 (NM_022769.4) | 2 of 5 (NM_032427.3) | Negative |
| 69 | AcCC | Negative | - | - | N/A |
| 70 | AcCC | Negative | - | - | N/A |
| 71 | AcCC | Negative | - | - | N/A |
| 72 | AcCC | Negative | - | - | N/A |
| 73 | AcCC | Negative | N/A | ||
| 74 | HCCC | EWSR1-ATF1 | 12 of 18 (NM_013986.3) | 3 of 7 (NM_005171.4) | N/A |
| 75 | HCCC | Negative | - | - | N/A |
| 76 | HCCC | EWSR1-ATF1 | 14 of 18 (NM_013986.3) | 5 of 7 (NM_005171.4) | N/A |
| 77 | SC | ETV6-NTRK3 | 5 of 8 (NM_001987.4) | 15 of 20 (NM_001012338.2) | N/A |
| 78 | SC | ETV6-NTRK3 | 5 of 8 (NM_001987.4) | 15 of 20 (NM_001012338.2) | N/A |
| 79 | SDC | RAPGEF6-ACSL6 | 1 of 29 (NM_001164386.1) | 2 of 21 (NM_015256.3) | N/A |
| 80 | IC | NCOA4-RET | 8 of 12 (NM_001145260.1) | 12 of 20 (NM_020975.5) | N/A |
Stochastic events highlighted by an asterisk (*).