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. 2021 Jun 24;30(1):209–222. doi: 10.1016/j.ymthe.2021.06.016

Figure 4.

Figure 4

Tracking of CD33 off-target editing in granulocytes over time

The left graph for each animal has a y axis fixed at 100%. The y axis shows fraction of edited alleles at each off-target site in relation to the on-target site ISP1,CS1 (blue dashed line). The right graph for each animal only shows the off-target sites with the y axis adjusted to allow visualization of the editing levels for each site. The sites are designated in the legend by their CS and/or ISP ranking.