Table 1.
Information of the analyzed SNPs of the ADD1 and GNB3 genes
| Gene | SNP | Chr |
Physical
location |
Region in gene |
Alleles (major/ minor) |
MAF |
HW P-value |
|---|---|---|---|---|---|---|---|
| ADD1 | rs4690002 | 4 | 281 1038 | 5′ Flanking | C/T | 0.44 | 0.60 |
| rs12503220 | 4 | 281 9940 | intron 1 | G/A | 0.14 | 0.70 | |
| rs1263359 | 4 | 283 1824 | intron 1 | T/C | 0.43 | 0.93 | |
| rs17833172 | 4 | 283 8312 | intron 1 | G/A | 0.04 | 0.21 | |
| rs3775067 | 4 | 285 8420 | intron 4 | C/T | 0.34 | 0.77 | |
| rs4961 | 4 | 287 6505 | exon 9(missense) | T/G | 0.48 | 0.20 | |
| rs4963 | 4 | 288 6560 | exon12(missense) | G/C | 0.48 | 0.54 | |
| GNB3 | rs4963516 | 12 | 681 8289 | 5′ flanking | A/C | 0.32 | 0.12 |
| rs1129649 | 12 | 681 8729 | 5′ flanking | T/C | 0.31 | 0.61 | |
| rs3213431 | 12 | 681 8789 | 5′ flanking | T/C | 0.11 | 0.82 | |
| rs2301339 | 12 | 682 4885 | intron 9 | G/A | 0.45 | 0.66 | |
| rs5446 | 12 | 682 6723 | 3′ UTR | C/T | 0.20 | 0.68 |
Abbreviations: ADD1, α-adducin; GNB3, guanine nucleotide binding protein (G protein) β-polypeptide 3; H–W, Hardy–Weinberg equilibrium test; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.