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. Author manuscript; available in PMC: 2022 Jan 12.
Published in final edited form as: Oral Oncol. 2021 Jul 1;120:105420. doi: 10.1016/j.oraloncology.2021.105420

Figure 2. Major immunomodulatory T cell receptors and their ligands.

Figure 2.

Tumor cells hijack T cell function by inducing inhibitory receptors or by suppressing stimulatory receptors, either directly or indirectly through antigen presenting cells. Thus these receptor:ligand axes represent therapeutic targets for immunosuppressive HNSCC. APC=antigen presenting cell; PD=programmed death; PD-L=programmed death-ligand; CTLA=cytotoxic T-lymphocyte-associated protein; LAG=lymphocyte activating gene; TIM=T cell immunoglobulin and mucin domain-containing; TIGIT=T cell immunoglobulin and ITIM domain; ICOS=inducible T cell co-stimulator; GITR=glucocorticoid-induced TNFR-related protein; CD40=cluster of differentiation; MHC-II=major histocompatibility complex 2; Gal=galectin; PVR=poliovirus receptor. Cellular images are modified from Servier Medical Art (https://smart.servier.com), used under the terms of Creative Commons License 3.0.