Table 3.
Distribution of SMAD7 genotypes and allele frequency among colorectal cancer patients and controls
| Genetic model (HWE) | Genotype | Cases (n = 209) | Controls (n = 200) | p-value | OR (95%CI) | p-valueadj.* | OR (95%CI) adj.* |
|---|---|---|---|---|---|---|---|
| rs4939827 (0.1) | CC | 89(42.6%) | 78(40.0%) | Ref | |||
| CT | 83(39.7%) | 101(51.8%) | 0.12 | 0.72(0.47–1.09) | 0.294 | 0.75(0.43–1.29) | |
| TT | 37(17.7%) | 16(8.2%) | 0.036 | 2.02(1.04–3.92) | 0.024 | 2.49(1.13–4.49) | |
| Dominant model | TT + CT | 120 (57.4%) | 117 (60.0%) | Ref | |||
| CC | 89(42.6%) | 78(40.0%) | 0.598 | 1.11(0.75–1.65) | 0.920 | 1.03(0.62–1.70) | |
| Recessive model | CC + CT | 172 (82.3%) | 179 (91.8%) | Ref | |||
| TT | 37(17.7%) | 16(8.2%) | 0.006 | 2.40(1.29–4.48) | 0.005 | 2.90(1.38–6.09) | |
| Multiplicative model | C | 157(37.6%) | 133(34.1%) | Ref | |||
| T | 261(62.4%) | 257(65.9%) | 0.350 | 0.87 (0.65–1.16) | 0.189 | 0.78 (0.54–1.13) | |
| Co-dominant model | CT | 83(39.7%) | 101(51.8%) | Ref | |||
| CC + TT | 126 (60.3%) | 94 (48.2%) | 0.015 | 1.63 (1.10–2.42) | 0.049 | 1.66 (1.00–2.75) | |
| rs34007497 (0.98) | CC | 135 (64.6%) | 126 (63.0%) | Ref | |||
| CG | 52 (24.9%) | 66 (33.0%) | 0.168 | 0.73(0.47–1.14) | 0.183 | 0.68 (0.39–1.20) | |
| GG | 22 (10.5%) | 8 (4.0%) | 0.029 | 2.56 (1.10–5.97) | 0.327 | 1.71 (0.558–5.04) | |
| Recessive model | CC + CG | 187 (89.5%) | 192 (96.0%) | Ref | |||
| GG | 22 (10.5%) | 8 (4.0%) | 0.015 | 2.82(1.22–4.50) | 0.227 | 1.93 (0.66–5.59) | |
| Dominant model | GG + CG | 74 (35.4%) | 74 (37.0%) | Ref | |||
| CC | 135 (64.6%) | 126 (63.0%) | 0.737 | 1.07(0.71–1.60) | 0.379 | 0.79 (0.47–1.33) | |
| Multiplicative model | C | 96 (22.9%) | 82 (20.5%) | Ref | |||
| G | 322 (77.1%) | 318 (79.5%) | 0.393 | 1.16(0.83–1.63) | 0.788 | 0.94 (0.61–1.46) | |
| Co-dominant model | CC + GG | 157 (75.1%) | 134 (67.0%) | Ref | |||
| CG | 52 (24.9%) | 66 (33.0%) | 0.071 | 0.67 (0.44–1.03) | 0.135 | 0.65 (0.37–1.14) | |
| rs8085824 (0.53) | TT | 58 (28.9%) | 77 (38.5%) | Ref | |||
| CT | 97 (48.3%) | 100 (50.0%) | 0.013 | 0.48 (0.27–0.86) | 0.092 | 0.53 (0.26–1.11) | |
| CC | 46 (22.8%) | 23 (11.5%) | 0.002 | 2.06 (1.45–4.86) | 0.086 | 1.95 (0.91–4.20) | |
| Recessive model | CT + TT | 155 (77.1%) | 177 (88.5%) | Ref | |||
| CC | 46 (22.9%) | 23 (11.5%) | 0.042 | 1.54 (1.02–2.34) | 0.477 | 1.21 (0.71–2.07) | |
| Dominant model | CC + CT | 143 (71.1%) | 123 (61.5%) | Ref | |||
| TT | 58 (28.9%) | 77 (38.5%) | 0.003 | 0.44 (0.25–0.75) | 0.067 | 0.52 (0.26–1.05) | |
| Multiplicative model | T | 189 (56.4%) | 213 (45.6%) | Ref | |||
| C | 146 (43.6%) | 254 (54.4%) | 0.003 | 0.65 (0.49–0.86) | 0.150 | 0.76 (0.53–1.10) | |
| Co-dominant model | CC + TT | 104 (51.7%) | 100 (50.0%) | Ref | |||
| CT | 97 (48.3%) | 100 (50.0%) | 0.727 | 0.93 (0.63–1.38) | 0.537 | 0.85 (0.51–1.42) | |
| rs8088297 (0.67) | CC | 3 (1.4%) | 3 (1.5%) | Ref | |||
| AC | 15 (7.2%) | 33 (16.5%) | 0.367 | 0.35 (0.08–2.52) | 0.306 | 0.35 (0.05–2.62) | |
| AA | 191 (91.4%) | 164 (82.0%) | 0.853 | 1.16 (0.23–5.85) | 0.645 | 1.55 (0.23–10.33) | |
| Recessive model | CC + AC | 18 (8.6%) | 36 (18.0%) | Ref | |||
| AA | 191 (91.4%) | 164 (82.0%) | 0.006 | 2.33 (1.27–4.26) | 0.203 | 1.62 (0.77–3.40) | |
| Dominant model | AA + AC | 206 (98.6%) | 197 (98.5%) | Ref | |||
| CC | 3 (1.4%) | 3 (1.5%) | 0.957 | 0.96 (0.19–4.79) | 0.587 | 0.59 (0.09–3.92) | |
| Multiplicative model | C | 21 (5.02%) | 39 (9.7%) | Ref | |||
| A | 397 (94.98%) | 361 (90.3%) | 0.011 | 2.04 (1.18–3.54) | 0.319 | 1.41 (0.72–2.75) | |
| Co-dominant model | CC + AA | 194 (92.8%) | 167 (83.5%) | Ref | |||
| AC | 15 (7.2%) | 33 (16.5%) | 0.004 | 0.39 (0.20–0.74) | 0.129 | 0.54 (0.24–1.20) |
All statistically significant P-values are shown in bold
*Adjusted for age, sex and BMI