Table 2.
Volumes of normalized subcortical brain structures with between-groups comparisons
| Structure normalized [mm3] | Control n = 42 |
AIS n = 16 |
PVI n = 18 |
Control-AIS | Control-PVI | AIS-PVI |
|---|---|---|---|---|---|---|
|
Scaling factor for head size; mean (95% CI) |
1.38 (1.34–1.41) |
1.47 (1.40–1.55) |
1.51 (1.45–1.57) |
0.005 | < 0.0001 | 0.369 |
| Range of scaling factor | 1.15–1.62 | 1.26–1.69 | 1.32–1.69 | |||
|
Thalamus, ipsilesional; median (IQR)a |
11,548 (10930–11,948) |
9154 (5487–10,017) |
9177 (8355–10,069) |
< 0.0001 | < 0.0001 | 0.617 |
|
Thalamus, contralesional; mean (95% CI) |
11,009 (10787–11,230) |
10,312 (9872–10,752) |
10,676 (10257–11,095) |
0.003 | 0.128 | 0.171 |
|
Caudate nucleus, ipsilesional; mean (95% CI) |
5694 (5499–5889) |
4905 (4083–5727) |
4768 (4283–5252) |
0.064 | 0.001 | 0.756 |
|
Caudate nucleus, contralesional; mean (95% CI) |
5861 (5684–6037) |
5915 (5433–6397) |
5770 (5416–6123) |
0.787 | 0.638 | 0.537 |
|
Putamen, ipsilesional; median (IQR)a |
7355 (6979–7911) |
6332 (4198–7756) |
7103 (5981–7496) |
0.048 | 0.083 | 0.523 |
|
Putamen, contralesional; mean (95% CI) |
7326 (7130–7522) |
7851 (7355–8348) |
7217 (6889–7544) |
0.050 | 0.545 | 0.027 |
|
Globus pallidus, ipsilesional; median (IQR)a |
2443 (2331–2535) |
2138 (1646–2346) |
2231 (2099–2356) |
< 0.001 | < 0.001 | 0.277 |
|
Globus pallidus, contralesional; mean (95% CI) |
2501 (2443–2558) |
2465 (2318–2612) |
2540 (2397–2683) |
0.633 | 0.600 | 0.444 |
|
Hippocampus, ipsilesional; median (IQR)a |
5265 (4994–5451) |
4422 (3875–5049) |
4862 (4540–5283) |
0.004 | 0.031 | 0.125 |
|
Hippocampus, contralesional; mean (95% CI) |
5293 (5141–5445) |
5379 (5044–5714) |
5210 (4933–5486) |
0.586 | 0.583 | 0.361 |
|
Amygdala, ipsilesional, mean (95% CI) |
1610 (1504–1716) |
1421 (1212–1629) |
1537 (1377–1697) |
0.068 | 0.458 | 0.334 |
|
Amygdala, contralesional; mean (95% CI) |
1540 (1454–1626) |
1554 (1365–1743) |
1562 (1416–1709) |
0.877 | 0.796 | 0.936 |
|
Nucleus accumbens, ipsilesional; mean (95% CI) |
756 (711–801) |
524 (416–633) |
701 (601–802) |
< 0.0001 | 0.268 | 0.004 |
|
Nucleus accumbens, contralesional; median (IQR)a |
593 (534–692) |
631 (477–705) |
611 (523–686) |
0.924 | 0.790 | 0.904 |
Subcortical brain structures segmented using the FSL’s FIRST tool and the volumes normalized by the FSL’s SIENAX tool’s volumetric scaling factor in mm3. Abbreviations: CI Confidence interval, IQR interquartile range. Between-groups comparison, using ANOVA or Kruskal-Wallis test (in absence of normal distribution denoted by with a). After FDR correction, using level 0.05, the cutoff p-value for significance of a single comparison was 0.033