MK801 selectively reduces SR and DAAO expression in the frontal cortex. Protein levels of serine racemase (SR; A, C, E) and D-amino acid oxidase (DAAO; B, D, F) were measured in the frontal cortex (A, B), striatum (C, D) and hippocampus (E, F) of vehicle treated (n = 5; white bars) and MK801 treated (n = 6; black bars) mice. (G) Representative Western blot images using DAAO antibody on cerebellar and hippocampal tissue lysate to test antibody specificity. Values are expressed as the optical density (OD) normalized to vehicle treated values (% vehicle). Unpaired Student t-test was used for analysis. Asterisk (*) indicates significant differences from the vehicle treated group (frontal cortex SR: 0.0029, DAAO: 0.0096). All values represent the mean ± SEM.