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Examples of small molecule inhibitors and fusion proteins used in the treatment of IEI
| Small molecule | IEI |
|
Jakinibs: Tofacitinib (Jak1, Jak3) ruxolitinib (Jak1, Jak2) |
STAT1 and STAT3 GOF |
|
PI3Kδ inhibitors: leniolisib (under study) nemiralisib (under study) |
APDS1 and APDS2 |
| Fusion protein | IEI |
| Abatacept | CTLA-4 and LRBA deficiencies |
