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. 2021 Dec 23;23(2):168. doi: 10.3892/etm.2021.11091

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Gastrodin inhibits HG-induced inflammation and oxidative stress by activating the 5'AMP-activated protein kinase/nuclear factor erythroid 2-related factor 2 signaling pathway in MPC5 cells. (A) The secretion of inflammatory cytokines, TNF-α, IL-1β and IL-6 were analyzed by ELISA. (B) The expression levels of MCP-1, NLRP3, ASC and Caspase-1 were determined by western blotting and quantified. (C) MDA levels and the activities of LDH and SOD were quantified using their respective assay kits. Error bars represent the mean ± SEM from three independent experiments. ^**P<0.01 and ^***P<0.001 vs. HG. ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. HG + 100 µM gastrodin. HG, high glucose; LDH, lactate dehydrogenase; SOD, superoxide dismutase; MDA, malondialdehyde; MCP-1, monocyte chemoattractant protein 1; ASC, apoptosis-associated speck-like protein; NLRP3, NOD-, LRR- and pyrin domain-containing protein 3.