Table 1.

Results of human laboratory studies investigating the socio-emotional effects of MDMA and other stimulant drugs.

Measure	Study	N	MDMA	Effect	Other stimulant	Effect
Mood states
Friendly (POMS or VAS)	Bedi et al., 2009	9	1.5 mg/kg	↑	—	—
	Tancer and Johanson, 2003	12	1 mg/kg	NE	10 mg d-amph	NE
			2 mg/kg	↑	20 mg d-amph	↑
	Van Wei et al., 2012	17	75 mg	↑	—	—
	Harris et al., 2002	8	1.5 mg/kg	↑	—	—
	Bedi et al., 2010	21	0.75 mg/kg	NE	—	—
			1.5 mg/kg	↑
	Johanson et al., 2006	8	1.0 mg/kg	↑	20 mg d-amph	↑
			1.5 mg/kg	↑
Social (VAS)	Tancer and Johanson, 2003	12	1 mg/kg	NE	10 mg d-amph	NE
			2 mg/kg	↑	20 mg d-amph	↑
	Kirkpatrick et al., 2012	11	100 mg	↑	20 mg meth	↑
					40 mg meth	↑
	Bedi et al., 2010	21	0.75 mg/kg	NE	20 mg meth	↑
			1.5 mg/kg	NE
Talkative (VAS)	Tancer and Johanson, 2003	12	1 mg/kg	NE	10 mg d-amph	NE
			2 mg/kg	↑	20 mg d-amph	↑
	Kirkpatrick et al., 2012	11	100 mg	↑	20 mg meth	—
					40 mg meth	↑
Ratings of emotional images (IAPS)
Positive ratings for images with social content only	Wardle et al., 2014	101	0.75 mg/kg	NE	—	—
			1.5 mg/kg	↑
Positive ratings of images with and without social content	Wardle and de Wit, 2012	36	—	—	10 mg d-amph	NE
					20mg d-amph	↑
Emotional empathy (MET)
For both positive and negative situations	Hysek et al., 2014a	32	125 mg	↑	—	—
	Kuypers et al., 2014	30	75 mg	↑	—	—
For positive situations only	Schmid et al., 2014	30	75 mg	↑	40 mg methylphenidate	NE
Emotion recognition (FERT, RMET, DEIT)
Recognition: all emotions	Wardle et al., 2012	36	—	—	10 mg d-amph	NE
					20 mg d-amph	↑
Recognition: anger	Wardle et al., 2014	36	0.75 mg/kg; 1.5 mg/kg	NE ↓	—	—
Recognition: sadness	Schmid et al., 2014	30	75 mg	↓	40 mg methylphenidate	NE
Recognition: anger and fear	Kirkpatrick et al., 2014b	65	0.75 mg/kg 1.5 mg/kg	NE ↓	—	—
Recognition: fear	Bedi et al., 2010	21	0.75 mg/kg	NE	20 mg meth	NE
			1.5 mg/kg	↓
Recognition: negative emotions	Hysek et al. 2014a	32	125 mg MDMA	↓	—	—
	Hysek et al., 2014b	16	125 mg MDMA	↓	60 mg methylphenidate	↑
Psychophysiological responses
Positive responses to happy faces	Wardle and De Wit, 2014	36	0.75 mg/kg 1.5 mg/kg	NE ↑	—	—
Positive responses to positive stimuli	Wardle et al., 2012	36	—	—	10 mg d-amph	NE
					20 mg d-amph	↑
Amygdala responses to negative faces	Bedi et al., 2010	9	1.5 mg/kg	↓	—	—
	Hariri et al., 2002	12	—	—	0.25 mg/kg	↑
Ratings of erotic images	Schmid et al., 2015b	30	75 mg	NE	40 mg methylphenidate	↑
Speech
Quantity	Marrone et al., 2010	11	100 mg	NE	20 mg meth	↑
					40 mg meth	↑
	Ward et al., 1997	6	—	—	5 mg d-amph	--
					10 mg d-amph	↑
	Griffiths et al., 1977	7	—	—	5–30 mg d-amph	↑
	Wardle et al., 2012	36	—	—	10 mg d-amph	NE
					20mg d-amph	↑
Fluency	Marrone et al., 2010	11	100 mg	↓	20 mg meth	↑
					40 mg meth	↑
Content	Baggott et al. 2016		1.5 mg	↑	—	—
Social words
	Bedi et al., 2014		0.75 mg/kg 1.5 mg/kg	NE ↑	20 mg meth	NE
Effects of social interactions on drug responses
Subjective effects	Kirkpatrick et al., 2015	32	0.5 mg/kg 1.0 mg/kg	NE ↑	—	—
	de Wit et al., 1997	42	—	—	10 mg d-amph	NE
					20 mg d-amph	NE
Physiological effects (heart rate, blood pressure)	de Wit et al., 1997	42	—	—	10 mg d-amph	NE
					20 mg d-amph	↑
	Zacny et al., 1992	8	—	—	20 mg d-amph	NE
	Kirkpatrick etal., 2015	32	0.5 mg/kg; 1.0 mg/kg	NE ↑	—	—

MDMA: ±3,4-methylenedioxymethamphetamine; ↑: increase; ↓: decrease; NE: no effect; VAS: Visual Analogue Scale; POMS: Profile of Mood States; MET: Multifaceted Empathy Test; FERT: Facial Emotion Recognition Test; RMET: Reading the Mind in the Eyes Test; d-amph: d-amphetamine; meth: methamphetamine.