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. Author manuscript; available in PMC: 2022 Jan 12.
Published in final edited form as: ACS Chem Neurosci. 2019 Oct 28;10(11):4558–4570. doi: 10.1021/acschemneuro.9b00415

Table 2.

Summary of EC50 or EC80 Values of Quis and Quis + LY393053 in mGlu5/HEK Cells and Striatal, Hippocampal, and Cortical Culturesa

mGlu5 HEK striatal hippocampal cortical
Quis EC50 31.0 ± 8.3 nM 1.31 ± 0.36 μM 122 ± 12.1 nM 168 ± 55.8 nM
Quis with LY393053 EC50 1.33 ± 0.15 μM 225 ± 35.7 nM* 301 ± 59.2 nM**
Quis EC80 125 ± 32.3 nM 5.25 ± 1.43 μM 515 ± 51.4 nM 670 ± 223 nM
max fluorescence response (Emax); (Quis with LY393053)/Quis (%) 97.1 ± 0.565 84.5 ± 1.75* 89.1 ± 2.29
a

EC50 and EC80 values of Quis were determined from the dose–response curves in Figure 3 using GraphPad Prism.

EC50: *P < 0.05, **P < 0.01 compared to Quis without LY393053. Emax: *P < 0.05 compared to Quis without LY393053.