Table 3.

Summary of IC₅₀ Values of Various mGlu₅ NAMs in mGlu₅/HEK Cells and Striatal, Hippocampal, and Cortical Cultures^a

	IC50
NAM	mGlu5 HEK	striatal	hippocampal	cortical
MPEP	42.4 ± 7.5 nM	1.13 ± 0.36 μM	41.7 ± 4.7 nM	119 ± 34.1 nM
Fenobam	178 ± 40 nM	2.93 ± 0.48 μM	442 ± 150 nM	807 ± 53.5 nM
AFQ056	37.6 ± 8.9 nM	9.44 ± 3.78 μM	257 ± 27.4 nM	270 ± 73.0 nM
RG7090	1.76 ± 0.88 nM	62.0 ± 17.5 nM	8.97 ± 3.40 nM	80.2 ± 16.8 nM
AZD2066	27.2 ± 9.1 nM	3.56 ± 0.52 μM	96.2 ± 17.8 nM	380 ± 78.0 nM

^aThe IC₅₀ values of various mGlu₅ NAMs were determined from the inhibition curves in Figure 4 using GraphPad Prism.