Table 4.

Summary of Lipophilic Ligand Efficiency (LLE) Values of Tested mGlu₅ NAMs in mGlu₅/HEK Cells and Striatal, Hippocampal, and Cortical Cultures^a

	LLE
	mGlu5 HEK	striatal	hippocampal	cortical
MPEP	4.22	2.80	4.23	3.77
Fenobam	5.50	2.38	3.20	2.94
AFQ056	4.57	1.88	3.44	3.42
RG7090	4.59	4.06	4.90	3.95
AZD2066	4.29	2.30	3.87	3.27

^aLLE = pIC₅₀ − log P.^42–46 Consensus log P_o/w of each drug listed in Table 1 and IC₅₀ listed on Table 3 were used to calculate the LLE for each NAM.