Table 5.
Nucleotide and amino acid substitutions in amikacin-heteroresistant K. pneumoniae S38 and the resistant subpopulation S38L.
| Isolates | Gene or CDsa/Product or function | Mutations | |
|---|---|---|---|
| Nucleotide | Amino acid | ||
| S38/S38L | parB, accurate chromosome segregation in bacteria | C 678 T T 708 C G 1248 T C 1688 T |
Ala 226 Val Ile 236 Thr Gln 476 His Ser 563 Phe |
| S38/S38L | CDs, Capsid size determination protein Sid | A 140 C G 141 A |
Glu 47 Ala |
| S38/S38L | CDs, Carbohydrate porin | A 244 C C 246 G |
Ile 82 leu |
| S38/S38L | CDs, Sequence-specific DNA-binding transcription factor | A 402 G | Ile 134 Met |
| S38/S38L | Ssb, Single-stranded DNA-binding protein | T 46 A A 167 G |
Trp 16 Arg His 56 Arg |
| S38/S38L | CDs, Threonine dehydrogenase | G 90 T A 97 T A 124 T T 167 A C 277 T |
Met 30 Ile Ser 33 Cys Ser 42Cys Val 56 Glu Arg 93 Trp |
| S38/S38L | CDs, Hypothetical protein PUUH_pUUH2392p0081 | C 46 A C 161 A G 184 C G 223 A |
Arg 16 Ser Ala 54 Glu Val 62 Leu Val 75 Ile |
| S38/S38L | CDs, DUF905 domain-containing protein | G 139 A T 221 A A 230 G |
Val 47 Ile Phe 74 Tyr Glu 77 Gly |
a
CDs, complete coding sequence.