TABLE 3.
Association analysis between polygenic score for PA, dementia end points, and death.
| Phenotype | Cases/Controls | OR | P | β | SE |
|---|---|---|---|---|---|
| Dementia, all | 7,284/209,487 | 1.01 | 0.4743 | 0.0108 | 0.0128 |
| Alzheimer disease | 3,899/214,893 | 1.05 | 0.0112 | 0.0462 | 0.0170 |
| Alzheimer’s disease, atypical or mixed | 800/214,893 | 1.09 | 0.0262 | 0.0863 | 0.0361 |
| Alzheimer’s disease, early onset | 587/111,471 | 1.08 | 0.1199 | 0.0724 | 0.0419 |
| Alzheimer’s disease, late onset | 2,670/111,471 | 1.02 | 0.3794 | 0.0218 | 0.0216 |
| Vascular dementia | 859/211,300 | 0.99 | 0.7712 | −0.0120 | 0.0346 |
| Any death | 15,152/203,640 | 0.97 | 0.0003 | −0.0335 | 0.0088 |
Logistic regression analysis. Model adjusted for age, sex, and 10 genetic principal components of population stratification.