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. 2022 Jan 12;130(1):017005. doi: 10.1289/EHP9373

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Figure 8 is a schematic illustration having two steps. Step 1: Macrophage, including peroxisome proliferator-activated receptor lowercase alpha and peroxisome proliferator-activated receptor gamma, diethylhexyl phthalate, M 1 with I L-6 T N F lowercase alpha, and M 2 with I L-1 R A, I L-10 lead to Hepatocyte. Step 2: Hepatocyte, including lipid uptake, mono(2-ethylhexyl) phthalate, lipid synthesis, citrate, peroxisome proliferator-activated receptor lowercase alpha, and mitochondria lead to fatty liver and oxidative phosphorylation with F A O and T C A lead to lipid homeostasis. — Schematic illustration for the impact of macrophage-specific $peroxisome proliferator-activated receptor lowercase alpha$ and $peroxisome proliferator-activated receptor lowercase gamma$ activation on the fatty liver induction by DEHP. Note: DEHP, diethylhexyl phthalate; FAO, fatty acid oxidation; IL, interleukin; MEHP, mono(2-ethylhexyl) phthalate; OXPHOS, oxidative phosphorylation; PPAR, peroxisome proliferator-activated receptor; TCA, tricarboxylic acid cycle; TNF, tumor necrosis factor.