Table 3.

Comparison of PRSi distribution between patients with and without toxicity. Comparison of the polygenic risk score incorporating SNP-SNP interactions (PRSi) distribution for patients with and without toxicity (separately for each of the 5 considered toxicity endpoints). The PRSi medians in the two classes are reported and compared with the Wilcoxon test for independent samples; the p-value of such test is reported (third row). The distribution of the score as a whole is also compared in the two classes using the Kolmogorov-Smirnov two-samples test; p-values of the latter are reported in the table (last row). ▼.

	Late Urinary Frequency grade ≥ 2	Late Haematuria grade ≥ 1	Late Nocturia grade ≥ 2	Late Decreased Urinary Stream grade ≥ 1	Late Rectal Bleeding grade ≥ 1
Median (patients with toxicity)	0.611	0.740	−0.149	0.168	0.208
Median (patients without toxicity)	−0.357	0.033	−0.224	−0.133	0.001
Wilcoxon	p = 5.76e-13	p = 9.73e-10	p = 3.48e-07	p = 2.35e-16	p = 8.73e-08
Kolmogorov-Smirnov	p = 3.39e-10	p = 1.41e-06	p = 1.44e-04	p = 1.41e-14	p = 6.52e-06