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. 2022 Jan 12;17(1):e0262169. doi: 10.1371/journal.pone.0262169

Fig 3. Virus neutralization was confirmed in the vast majority of anti-spike IgG positive samples, and associated to COVID-19 symptoms.

Fig 3

A) Four-month follow-up anti-spike IgG levels in HCW or convalescent COVID-19 patients who were anti-spike IgG positive at study inclusion were significantly higher in serum from individuals with SARS-CoV-2 neutralizing potential compared to non-neutralizing samples. Purple: Anti-spike IgG positive individuals at four-month follow-up. Grey: Anti-spike IgG negative individuals at four-month follow-up. B) SARS-CoV-2 neutralizing potential of HCW who were anti-spike IgG positive at both study inclusion and follow-up was significantly associated with COVID-19 symptoms prior to study inclusion, shown with odds ratios of neutralization potential for individually self-reported symptoms C) Neutralization potential was not found in samples with high levels of anti-nucleocapsid IgG alone. Green: SARS-CoV-2 neutralizing potential. Brown: No SARS-CoV-2 neutralizing potential. Circles (panel A and C): HCW. Triangles: Convalescent COVID-19 patients. AU: Arbitrary Units. CI: Confidence Interval.