Fig. 3. Disruption of coexpression between key de novo genes.
(A) Coexpression between FBL, SETD5, KDM3B, and ASXL3 and neurotransmitter (glutamate, serotonin, and dopamine)–related genes in the prefrontal cortex of patients with OCD. Each dot represents a gene involved in one neurotransmitter system, and the Y axis shows the absolute differences in the coexpression (ΔCo-exp) between patients and controls. P values were calculated using Fisher’s tests and indicate whether ΔCo-exp was significantly larger than expected. (B) Disruptions caused by KDM3B and SETD5 had opposite trends. For each neurotransmitter system, the ΔR values of SETD5 and KDM3B were plotted against each other, and their correlations were calculated.