Table 3.
Association Between Plasma TMAO and Severity of Coronary Atherosclerosis in Patients with Different eGFR Levels
| Non-Adjusted Model | Adjusted Model | P for Interaction | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | |||
| TVD | ||||||
| eGFR <60 mL/min/1.73 m2 (n = 80) | <0.001 | |||||
| Tertiles of TMAO | T1-2 | 1.00 | 1.00 | |||
| T3 | 4.12 (1.59, 10.64) | 0.004 | 25.28 (2.55, 250.33) | 0.006 | ||
| eGFR ≥60 mL/min/1.73 m2 (n = 269) | ||||||
| Tertiles of TMAO | T1-2 | 1.00 | 1.00 | |||
| T3 | 0.78 (0.39, 1.56) | 0.489 | 0.75 (0.32, 1.78) | 0.517 | ||
| SYNTAX score >22 | ||||||
| eGFR <60 mL/min/1.73 m2 (n = 80) | 0.040 | |||||
| Tertiles of TMAO | T1-2 | 1.00 | 1.00 | |||
| T3 | 2.99 (1.18, 7.54) | 0.021 | 7.23 (1.51, 34.64) | 0.013 | ||
| eGFR ≥60 mL/min/1.73 m2 (n = 269) | ||||||
| Tertiles of TMAO | T1-2 | 1.00 | 1.00 | |||
| T3 | 1.37 (0.71, 2.64) | 0.341 | 1.23 (0.52, 2.90) | 0.635 | ||
Note: The adjusted model was adjusted for all of these variables, including age, sex, BMI, hypertension, active smoking, diabetes duration, FBG, HbA1c, LDL-C, HDL-C and TG.