Table 2.
Population PK Model Parameter Estimates
| Parameter | Estimate (%RSE) (95% CI) [%Shrinkage] | Bootstrap Median (95% CI) |
|---|---|---|
| Typical Values | ||
| CL (L/h) | 13.7 (7.4) (11.8–15.7) | 13.6 (11.7–16.1) |
| Vc (L) | 25.5 (8.5) (21.3–29.7) | 24.8 (19.9–30.4) |
| Vp (L) | 12.4 (15.8) (8.6–16.2) | 12.7 (8.5–19.4) |
| Q (L/h) | 8.1 (32.6) (2.9–13.3) | 8.6 (3.5–15.7) |
| eCrClCG on CL | 0.64 (20.9) (0.37–0.90) | 0.64 (0.34–0.90) |
| Interindividual variability | ||
| IIV on CL (%CV) | 57.8 (12.2) (44–71.6) [3] | 56.8 (43–75.9) |
| IIV on Vc (%CV) | 57 (16.8) (38.2–75.8) [14] | 56.6 (31.3–78.9) |
| IIV on Vp (%CV) | 74.4 (24.5) (38.6–110.1) [25] | 77.2 (34.6–146.6) |
| Correlation between CL & Vc | 0.185 | 0.178 (0.054–0.373) |
| Residual variability | ||
| Additive residual variability (mg/L) | 0.147 (45.6) (0.1–0.19) [16] | 0.155 (0.002–0.782) |
| Proportional residual variability (%CV) | 31.1 (17.2) (21.34–40.9) [16] | 29.1 (21.2–39.4) |
Notes: The model dOFV was 1655.702. 1831 out 2000 bootstrap runs (91.5%) were successful. The condition number was 99.74.
Abbreviations: CI, confidence interval; CL, clearance; CV, coefficient of variation calculated as 
; eCrClCG, creatinine clearance according to the Cockcroft-Gault equation; interindividual variability; Q, Intercompartmental clearance; RSE, root mean square error; Vc, volume of the central compartment; Vp, volume of the peripheral compartment.