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DMOG reversed the neuroprotective effect of celastrol on cerebral I/R injury. (a) Neurological score in different groups (n = 3 − 4). (b) Representative images of TTC staining. (c) Quantification of cerebral infarct volume in different groups (n = 3 − 4). The data are presented as mean ± SEM. ∗∗∗∗P < 0.0001 compared with the sham group; ##P < 0.01 and ####P < 0.0001 compared with the I/R group; @P < 0.05 and @@P < 0.001 compared with the I/R + Celastrol group.
