Table 2.
Summary of efficacy endpoints between hypochlorous acid (HOCL) and placebo groups.
| Visit duration | HOCL (n = 27), mean ± SEM | Placebo (n = 26), mean ± SEM | p value by ANOVA for HOCL vs. placebo |
|---|---|---|---|
| (a) Ocular surface disease index (OSDI) scores | |||
| 1st day | 18.65 ± 5.20 | 21.54 ± 4.98 | 0.058 |
| 15th day | 14.25 ± 4.45 | 13.68 ± 5.02 | 0.061 |
| 30th day | 11.14 ± 4.14 | 10.89 ± 4.98 | 0.055 |
| 55th day | 8.08 ± 4.32 | 9.00 ± 6.68 | 0.052 |
| (b) Schirmer's test average of both eyes | |||
| 1st day | 7.09 ± 2.34 | 6.65 ± 1.82 | 0.411 |
| 15th day | 9.22 ± 2.12 | 7.64 ± 2.04 | 0.053 |
| 30th day | 12.28 ± 3.28 | 9.90 ± 4.21 | <0.05∗ |
| 55th day | 13.38 ± 2.73 | 9.92 ± 2.12 | <0.01∗∗ |
| (c) Tear film break-up time (TBUT) average of both eyes | |||
| 1st day | 4.78 ± 1.12 | 4.86 ± 1.02 | 0.423 |
| 15th day | 4.89 ± 1.56 | 4.97 ± 1.25 | 0.351 |
| 30th day | 6.13 ± 1.13 | 6.09 ± 1.08 | 0.459 |
| 55th day | 9.22 ± 1.41 | 7.32 ± 1.72 | <0.05∗ |
| (d) Conjunctivae labeling average of both eyes | |||
| 1st day | 0.86 ± 0.19 | 0.88 ± 0.20 | 0.677 |
| 55th day | 0.41 ± 0.27 | 0.65 ± 0.25 | <0.01∗∗ |
| (e) Corneal labeling average of both eyes | |||
| 1st day | 1.05 ± 0.09 | 1.24 ± 0.12 | 0.406 |
| 55th day | 0.68 ± 0.11 | 0.82 ± 0.09 | <0.05∗ |