Table 4.
Drug targets of IS. (The average degree value is 8.670412, and the average medium is 0.20796.)
| Gene | Protein name | Degree | Betweenness centrality |
|---|---|---|---|
| MAPK1 | Mitogen-activated protein kinase 1 | 53 | 0.126385 |
| SRC | Proto-oncogene tyrosine-protein kinase Src | 50 | 0.052449 |
| PIK3R1 | 47 | 0.047873 | |
| HRAS | GTPase HRas | 44 | 0.033552 |
| AKT1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 40 | 0.109791 |
| RHOA | Transforming protein RhoA | 35 | 0.047081 |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 | 34 | 0.0268 |
| HSP90AA1 | Heat shock protein HSP 90-alpha | 33 | 0.059285 |
| RXRA | Retinoic acid receptor alpha， RAR-alpha | 30 | 0.067159 |
| FN1 | Fibronectin 1 | 29 | 0.023024 |
| MAPK8 | Mitogen-activated protein kinase 8 | 29 | 0.022235 |
| ESR1 | Estrogen receptor | 28 | 0.091184 |
| MAPK14 | Mitogen-activated protein kinase 14 | 28 | 0.058202 |
| NCOA1 | Nuclear receptor coactivator 1 | 27 | 0.039326 |
| CREBBP | CREB binding protein | 26 | 0.03777 |
| IGF-1 | Insulin-like growth factor I | 25 | 0.024056 |
| ALDOA | Fructose-bisphosphate aldolase A | 22 | 0.065989 |
| RAP1A | Ras-related protein Rap-1A | 21 | 0.026304 |
| B2M | Beta-2-microglobulin | 19 | 0.034377 |
| PLG | Plasminogen | 19 | 0.023626 |
| F2 | Prothrombin | 16 | 0.028418 |
| ARG1 | Arginase-1 | 16 | 0.021575 |
| CTSD | Cathepsin D | 15 | 0.037545 |
| PPARA | Peroxisome proliferator-activated receptor alpha | 15 | 0.028961 |
| CDA | Cytidine deaminase | 14 | 0.059555 |
| TYMS | Thymidylate synthase | 11 | 0.037145 |
| NOS3 | Nitric oxide synthase 3 | 11 | 0.036816 |
| DUT | Deoxyuridine triphosphatase | 9 | 0.057749 |
| NT5M | 5′(3′)-Deoxyribonucleotidase, mitochondrial | 9 | 0.048718 |
| G6PD | Glucose-6-phosphate dehydrogenase | 9 | 0.027099 |