Table 2.
Incidence Rates and Hazard Ratios of Coronavirus Disease 2019 Diagnosis and Hospitalization Among Recombinant Zoster Vaccinated Versus Unvaccinated Individuals
| No. of Doses | Vaccinated | Unvaccinated | Hazard Ratio (95% CI) | |||||
|---|---|---|---|---|---|---|---|---|
| No. of Cases | No. of PY | Incidence per 1000 PY (95% CI) | No. of Cases | No. of PY | Incidence per 1000 PY (95% CI) | Unadjusted | Adjusteda | |
| ≥1 RZV dose | (n = 149 244) | (n = 298 488) | ||||||
| COVID-19 diagnosis | 5951 | 121 887.27 | 48.82 (47.60–50.08) | 13 028 | 236 826.63 | 55.01 (54.07–55.96) | 0.86 (.84–.89) | 0.84 (.81–.87) |
| COVID-19 hospitalization | 1066 | 122 689.85 | 8.69 (8.18–9.23) | 2765 | 238 530.10 | 11.59 (11.17–12.03) | 0.73 (.68–.79) | 0.68 (.64–.74) |
| 2 RZV doses | (n = 94 895) | (n = 189 790) | ||||||
| COVID-19 diagnosis | 3403 | 77 714.97 | 43.79 (42.34–45.28) | 7689 | 150 668.58 | 51.03 (49.90–52.19) | 0.83 (.80–.87) | 0.81 (.77–.84) |
| COVID-19 hospitalization | 612 | 78 164.05 | 7.83 (7.23–8.48) | 1676 | 151 656.50 | 11.05 (10.53–11.59) | 0.69 (.63–.76) | 0.64 (.58–.70) |
| 1 RZV dose only | (n = 54 349) | (n = 108 698) | ||||||
| COVID-19 diagnosis | 2548 | 44 172.30 | 57.68 (55.49–59.97) | 5339 | 86 158.05 | 61.97 (60.33–63.65) | 0.92 (.88–.97) | 0.86 (.82–.91) |
| COVID-19 hospitalization | 454 | 44 525.79 | 10.20 (9.30–11.18) | 1089 | 86 873.60 | 12.54 (11.81–13.30) | 0.81 (.73–.91) | 0.76 (.68–.86) |
Abbreviations: CI, confidence interval; COVID-19, coronavirus disease 2019; PY, person-years; RZV, recombinant zoster vaccine.
Adjusted for covariates: body mass index, smoking, number of outpatient visits, hypertension (model for ≥1 RZV dose and 1 RZV dose only), and other vaccinations.