Figure 1.

Trial-level treatment effect correlation between disease-free survival (DFS) and overall survival (OS). A) Three-year DFS vs 5-year OS. B) Three-year DFS vs 6-year OS. C) Three-year DFS vs 6.5-year OS. The circle or triangle size is proportional to the number of patients in each comparison. The solid line indicates fitted weighted least squares (WLS) regression line; gray dashed lines indicate 95% prediction limits. Triangles indicate trial comparisons with irinotecan, circles indicate comparisons with oxaliplatin, and black and gray colors indicate comparisons with and without biologics, respectively. HR = hazard ratio.