Table 2.
Patient and disease characteristicsa
| Control arm | Experimental arm | Total | |
|---|---|---|---|
| Characteristic | (n = 8722) | (n = 9624) | (n = 18 396) |
| Age, No. (%), y | |||
| <50 | 1775 (20.2) | 1969 (20.5) | 3744 (20.4) |
| 50-64 | 4114 (46.9) | 4548 (47.3) | 8662 (47.1) |
| ≥65 | 2883 (32.9) | 3107 (32.3) | 5990 (32.6) |
| BMI, No. (%), kg/m² | |||
| <18.5 | 180 (2.1) | 227 (2.4) | 407 (2.2) |
| 18.5-25 | 3394 (38.8) | 3820 (39.9) | 7214 (39.4) |
| >25 | 5172 (59.1) | 5538 (57.8) | 10710 (58.4) |
| Missing | 26 | 39 | 65 |
| Sex, No. (%) | |||
| Female | 4026 (45.9) | 4438 (46.1) | 8464 (46.0) |
| Male | 4746 (54.1) | 5186 (53.9) | 9932 (54.0) |
| Tumor grade, No. (%) | |||
| Low grade | 6529 (78.9) | 7288 (79.8) | 13817 (79.4) |
| High grade | 1745 (21.1) | 1850 (20.2) | 3595 (20.6) |
| Missing | 498 | 486 | 984 |
| Performance score, No. (%) | |||
| 0 | 6645 (76.4) | 7327 (76.8) | 13972 (76.6) |
| 1 | 1952 (22.4) | 2084 (21.9) | 4036 (22.1) |
| 2 | 100 (1.1) | 124 (1.3) | 224 (1.2) |
| Missing | 75 | 89 | 164 |
| T-Stage, No. (%) | |||
| T1 or 2 | 1049 (12.4) | 1094 (11.8) | 2143 (12.1) |
| T3 | 6281 (74.4) | 6833 (73.5) | 13114 (73.9) |
| T4 | 1111 (13.2) | 1368 (14.7) | 2479 (14.0) |
| Missing | 331 | 329 | 660 |
| N-Stage, No. (%) | |||
| N1 | 5526 (63.0) | 5964 (62.0) | 11490 (62.5) |
| N2 | 3246 (37.0) | 3660 (38.0) | 6906 (37.5) |
| Tumor location, No. (%) | |||
| Distal only | 3749 (55.4) | 3618 (53.9) | 7367 (54.7) |
| Proximal only | 2975 (44.0) | 3051 (45.5) | 6026 (44.7) |
| Distal and proximal | 38 (0.6) | 42 (0.6) | 80 (0.6) |
| Missing | 2010 | 2913 | 4923 |
| Risk group, No. (%) | |||
| High risk (T4 or N2) | 3867 (45.1) | 4397 (46.7) | 8264 (45.9) |
| Low risk (T1-3 and N1) | 4700 (54.9) | 5022 (53.3) | 9722 (54.1) |
| Missing | 205 | 205 | 410 |
| Examined nodes, No. (%) | |||
| 0-7 | 1175 (15.7) | 1252 (15.0) | 2427 (15.4) |
| 8-12 | 1877 (25.1) | 1985 (23.9) | 3862 (24.4) |
| >12 | 4428 (59.2) | 5082 (61.1) | 9510 (60.2) |
| Missing | 1292 | 1305 | 2597 |
| Age | |||
| No. | 8772 | 9624 | 18 396 |
| Mean (SD) | 58.5 (10.89) | 58.3 (10.94) | 58.4 (10.92) |
| Median (range) | 59 (19.0, 85.0) | 59 (17.0, 86.0) | 59 (17.0, 86.0) |
| MSI/MMR status, No. (%) | |||
| MSS/MSI-low/pMMR | 3951 (87.5) | 3922 (87.6) | 7873 (87.6) |
| MSI-high/dMMR | 563 (12.5) | 556 (12.4) | 1119 (12.4) |
| Missing | 4258 | 5146 | 9404 |
| KRAS status, No. (%) | |||
| WT | 2715 (67.9) | 2707 (68.9) | 5422 (68.4) |
| MT | 1282 (32.1) | 1223 (31.1) | 2505 (31.6) |
| Missing | 4775 | 5694 | 10469 |
| BRAF status, No. (%) | |||
| WT | 4068 (87.9) | 3988 (87.5) | 8056 (87.7) |
| MT | 562 (12.1) | 570 (12.5) | 1132 (12.3) |
| Missing | 4142 | 5066 | 9208 |
a
BMI = body mass index; MMR = mismatch repair; MSI = microsatellite instability; MSS = microsatellite stable; MT = mutation; N = node; pMMR = proficient mismatch repair; T = tumor; WT = wild type.